Protective compositions for dermal papilla cells

US8247003B2 · kind B2 · utility

Inventors

• Muhammed Majeed · Plainsboro, US
• Kalyanam Nagabhushanam · Plainsboro, US
• Beena Bhat · Bengaluru, IN
• Geetha Kanhangad-Gangadharan · Bengaluru, IN
• Susmitha Anand-Tathapudi · Bengaluru, IN
• Pritee Paliwal · Bengaluru, IN

Key dates

• Filing date: Aug 7, 2009
• Grant date: Aug 21, 2012
• Expiry date: Apr 16, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/592
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel protective compositions for dermal papilla cells. In an embodiment the protective compositions of the present invention comprise 0.25% w/w or above of compositions comprising at least 10% w/w and above of 1-O-galloyl-β-D-glucose (β-glucogallin). In an embodiment, the said protective composition additionally comprises 50% to greater than 50% gallates including mucic acid 1,4-lactone 5-O-gallate, mucic acid 2-O-gallate, mucic acid 6-Methyl ester 2-O-gallate, mucic acid 1-Methyl ester 2-O-gallate and ellagic acid. In another embodiment the invention also encompasses synergistic protective compositions comprising the said protective compositions and 0.5% concentrate of liquid endosperm of Cocos nucifera, for dermal papilla directed towards helping the dermal papilla cells to form sufficient numbers and to retain a healthy morphology conducive for hair growth.