Method of detecting target molecule by using aptamer
US8247197B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 1, 2010 |
| Grant date | Aug 21, 2012 |
| Priority date | — |
| Expiry date | Sep 1, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/543
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An aptamer-probe complex for detecting the presence of a target molecule is disclosed. The complex of the present invention contains an aptamer moiety which is able to bind to an indicator protein and change the properties of the indicator protein, and a probe moiety which is able to bind to a target molecule, wherein the aptamer moiety and the probe moiety are combined in such a manner that the binding mode between the aptamer moiety and the indicator protein changes when the probe moiety binds to the target molecule. A target molecule can be detected with combination of an aptamer which binds to a certain protein, and a probe which binds to the target molecule, utilizing the properties of that protein as an indicator.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.