Patent · US Active

Sirtuin modulating compounds

US8247565B2 · kind B2 · utility

2Cited by

6References

17Claims

0Family size

Assignee

Sirtris Pharmaceuticals, Inc. · US

Inventors

Jean E. Bemis · Arlington, US
Jeremy S. Disch · Natick, US
Michael R. Jirousek · Cambridge, US
Walter Joseph Lunsmann · Harvard, US
Pui Yee Ng · Waltham, US
Chi B. Vu · Cambridge, US

Key dates

Filing date	Sep 27, 2010
Grant date	Aug 21, 2012
Priority date	—
Expiry date	Sep 27, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.