Patent · US Active

Process for preparing substituted 7-cyano quinone methides

US8247593B2 · kind B2 · utility

12Cited by
7References
13Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMay 13, 2008
Grant dateAug 21, 2012
Priority date—
Expiry dateMay 4, 2030

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07C253/30
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

A one-pot process of preparing a substituted 7-cyano quinone methide in which i) a substituted phenol is chloromethylated to form a substituted 4-chloromethylphenol; ii) converting the substituted 4-chloromethylphenol to a substituted 4-cyanomethylphenol; and iii) oxidizing the substituted 4-cyanomethylphenol to the substituted 7-cyano quinone methide, where steps i)-iii) are carried out in a single reaction vessel in a solvent system comprising water and one or more organic solvents and where after steps i) and ii) the aqueous portion of the reaction mixture is removed and the reagents for the subsequent step are added in aqueous solution. The 7-cyano quinone methides are effective inhibitors of the polymerization of reactive monomers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.