Osmotic device containing amantadine and an osmotic salt
US8252331B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 28, 2005 |
| Grant date | Aug 28, 2012 |
| Priority date | — |
| Expiry date | Mar 13, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0004
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo-zero order or sigmoidal release profile by increasing the amount of the osmotic salt in the core of the device. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.