Patent · US Active

Diagnosing pneumococcal pneumonia

US8252546B2 · kind B2 · utility

17Cited by
16References
10Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 17, 2007
Grant dateAug 28, 2012
Priority date—
Expiry dateOct 24, 2028

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2400/10
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.