Thermally-targeted delivery of medicaments including doxorubicin
US8252740B2 · kind B2 · utility
10Cited by
1References
14Claims
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Key dates
| Filing date | Jan 29, 2007 |
| Grant date | Aug 28, 2012 |
| Priority date | — |
| Expiry date | Jan 15, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat peptide, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) (SEQ ID NO: 3) spacer and a cysteine residue (SEQ ID NO: 4) conjugated to therapeutic such as doxorubicin, or an analog thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.