Patent · US Active

Quinolone carboxylic acids, derivatives thereof, and methods of making and using same

US8252783B2 · kind B2 · utility

0Cited by

5References

20Claims

0Family size

Assignee

BAUSCH & LOMB INCORPORATED · US

Inventors

Arthur E. Harms · Niskayuna, US
Ramakrishnan Arul · Jamkhed, IN
Anil Kumar Soni · Hyderabad, IN

Key dates

Filing date	Sep 17, 2009
Grant date	Aug 28, 2012
Priority date	—
Expiry date	Sep 4, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, Ib, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.