Process and compounds for the production of (+)opiates

US8252808B2 · kind B2 · utility

Assignee

• MALLINCKRODT LLC · US

Inventors

• Peter X. Wang · Chesterfield, US
• Tao Jiang · San Diego, US
• Gary L. Cantrell · Glen Carbon, US
• David W. Berberich · Saint Peters, US
• Bobby N. Trawick · Florissant, US
• Todd Osiek · Ballwin, US
• Subo Liao · Ballwin, US
• Frank W. Moser · Arnold, US
• Joseph P. McClurg · Hazelwood, US

Key dates

• Filing date: Dec 17, 2008
• Grant date: Aug 28, 2012
• Expiry date: Dec 12, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D489/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention generally provides processes and intermediate compounds useful for the production of (+)-opiates. Non-limiting examples of (+) opiates that may be derived from one or more compounds of the invention include (+)-noroxymorphone, (+)-naltrexone, (+)-naloxone, (+)-N-cyclopropylmethylnorhydrocodone, (+)-N-cycloproylmethylnorhydromorphone, (+)-N-allylnorhydrocodone, (+)-N-allylnorhydromorphone, (+)-noroxycodone, (+)-naltrexol, (+)-naloxol, and (+)-3-O-methyl-naltrexone.