Patent · US Active

Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

US8252824B2 · kind B2 · utility

8Cited by

2References

8Claims

0Family size

Assignee

Sanofi · FR

Inventors

Werngard Czechtizky · Frankfurt, DE
Zhongli Gao · Flemington, US
William Joseph Hurst · Oxford, US
Lothar Schwink · Stadtallendorf, DE
Siegfried Stengelin · Frankfurt am Main, DE

Key dates

Filing date	Nov 18, 2011
Grant date	Aug 28, 2012
Priority date	—
Expiry date	Nov 18, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I).wherein R, R1, R2, R3 and R4 are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.