S-triazolyl α-mercapto acetanilides as inhibitors of HIV reverse transcriptase

US8252828B2 · kind B2 · utility

Assignee

• Ardea Biosciences, Inc · US

Inventors

• Jean-Luc Girardet · San Diego, US
• Yung-hyo Koh · Irvine, US
• Martha Alicia De La Rosa · Morrisville, US
• Esmir Gunic · San Diego, US
• Zhi Hong · Chapel Hill, US
• Stanley Lang · Carlsbad, US
• Hong Woo Kim · Incheon, KR

Key dates

• Filing date: Jun 30, 2011
• Grant date: Aug 28, 2012
• Expiry date: Jun 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.