Kinesin inhibitors as cancer therapeutics
US8252832B2 · kind B2 · utility
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1References
9Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 25, 2008 |
| Grant date | Aug 28, 2012 |
| Priority date | — |
| Expiry date | Dec 19, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/61
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.