Membrane fusion proteins derived from reovirus
US8252901B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 4, 2010 |
| Grant date | Aug 28, 2012 |
| Priority date | — |
| Expiry date | Nov 4, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2720/12022
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.