Implants with membrane diffusion-controlled release of active ingredient

US8257729B2 · kind B2 · utility

Assignees

• BIOTRONIK VI Patent AG · CH
• Universitaet Rostock · DE
• Universitaet Greifswald · DE

Inventors

• Klaus-Peter Schmitz · Rostock, DE
• Detlef Behrend · Jülich, DE
• Katrin Sternberg · Rostock, DE
• Niels Grabow · Rostock, DE
• Claus Harder · Uttenreuth, DE
• Bjoern Klocke · Zürich, CH
• Heyo K. Kroemer · Neuenkirchen, DE
• Werner Weitschies · Neuenkirchen, DE

Key dates

• Filing date: Dec 10, 2008
• Grant date: Sep 4, 2012
• Expiry date: Jan 24, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/43
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.