Steroid-containing sustained release intraocular implants and related methods

US8257730B2 · kind B2 · utility

Assignee

• Allergan, Inc. · US

Inventors

• Glenn T. Huang · Fremont, US
• Thierry Nivaggioli · San Francisco, US
• Lon T. Spada · Walnut, US
• Hiroshi Sugimoto · Tecate Mission Road, US
• Wendy M. Blanda · Tustin, US
• James N. Chang · Newport Beach, US
• Orest Olejnik · Coto De Caza, US

Key dates

• Filing date: Apr 29, 2005
• Grant date: Sep 4, 2012
• Expiry date: Apr 25, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P27/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.