Patent · US Active

Immunostimulatory method

US8258107B2 · kind B2 · utility

3Cited by

21References

39Claims

0Family size

Assignee

Index Pharmaceuticals AB · SE

Inventors

Robert Lofberg · Djursholm, SE
Oliver Von Stein · Upplands Väsby, SE

Key dates

Filing date	Jun 29, 2006
Grant date	Sep 4, 2012
Priority date	—
Expiry date	Feb 19, 2028

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention makes it possible to enhance steroid efficacy in a steroid refractory or dependent patient afflicted with an inflammatory condition not responding or responding poorly or inadequately to anti-inflammatory treatment, by administering an oligonucleotide having the sequence 5 5′-Xm-CG-Yn-3′ in an effective amount to said patient and wherein X is A, T, C or G, Y is A, T, C, or G, m=1-100, n=1-100 and wherein at least one CG dinucleotide is ummethylated. The invention also encompasses the use of said oligonucleotide for the manufacture of pharmaceuticals.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.