Treatment or prevention of cancer and precancerous disorders
US8258181B2 · kind B2 · utility
1Cited by
11References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 23, 2006 |
| Grant date | Sep 4, 2012 |
| Priority date | — |
| Expiry date | Jul 15, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.