Patent · US Active

N-terminally chemically modified protein compositions and methods

US8258262B2 · kind B2 · utility

3Cited by

47References

14Claims

0Family size

Assignee

AMGEN INC. · US

Inventors

Olaf Kinstler · Newbury Park, US
Nancy E. Gabriel · Newbury Park, US
Christine E. Farrar · Newbury Park, US
Randolph B. DePrince · Terre Haute, US

Key dates

Filing date	Dec 16, 2009
Grant date	Sep 4, 2012
Priority date	—
Expiry date	Dec 16, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.