Exo- and diastereo- selective synthesis of himbacine analogs
US8258319B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Jun 24, 2011 |
| Grant date | Sep 4, 2012 |
| Priority date | — |
| Expiry date | Jun 24, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.