Anti-CTLA-4 antibodies with reduced blocking of binding of CTLA-4 to B7 and uses thereof
US8263073B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2009 |
| Grant date | Sep 11, 2012 |
| Priority date | — |
| Expiry date | Feb 4, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides isolated monoclonal antibodies that bind to CTLA-4 and that are capable of increasing the response of T cells to antigenic stimulation in vivo yet the antibodies do not substantially block the binding of CTLA-4 to B7 ligands (e.g., B7-1 and B7-2) in vitro. Thus, the antibodies of the invention demonstrate that is it possible to separate the immunostimulatory function of anti-CTLA-4 antibodies from their ability to block the binding of B7 ligands. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for increasing the response of T cells to antigenic stimulation using the antibodies of the invention, including methods for treating cancer using the antibodies of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.