Variants of group 1 allergens from Poaceae having reduced allergenicity and maintained T-cell reactivity

US8263090B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Helmut Fiebig · Schwarzenbek, DE
• Martin Wald · Hamburg, DE
• Andreas Nandy · Hamburg, DE
• Helga Kahlert · Hamburg, DE
• Bernahrd Weber · Hamburg, DE
• Oliver Cromwell · Bad Nenndorf, DE

Key dates

• Filing date: Jul 11, 2005
• Grant date: Sep 11, 2012
• Expiry date: Dec 28, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/57
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the preparation and use of variants of the group 1 allergens of the Poaceae (sweet grasses) which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially maintained reactivity with T-lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventive immunotherapy of grass pollen allergies.