Patent · US Active

Biological production of thymidine

US8263384B2 · kind B2 · utility

0Cited by

1References

5Claims

0Family size

Assignee

Glaxo Group Limited · GB

Inventors

David M. Anderson · Rockville, US
Andrew John Collis · Low Wood, GB
Lin Liu · Gainesville, US
Sergey Podkovyrov · Gaithersburg, US
Christopher Preston · Fort Collins, US

Key dates

Filing date	Feb 5, 2007
Grant date	Sep 11, 2012
Priority date	—
Expiry date	Jul 30, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P19/385
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.