Promoter and viral vector containing the same
US8263398B2 · kind B2 · utility
0Cited by
2References
7Claims
0Family size
Inventors
Key dates
| Filing date | Oct 19, 2010 |
| Grant date | Sep 11, 2012 |
| Priority date | — |
| Expiry date | Oct 19, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention constructs an activating KRASmutant but not p53-responsive promoter and generates an E1B-55kD-deleted (ΔE1B-55kD) adenovirus, harboring a transcriptionally activating transgene and holding lytic replication ability in the tumor cells with activating KRASmutant. The adenovirus of the invention can be used in the treatment of cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.