Prevention and treatment of osteoarthritis
US8263546B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Mar 19, 2009 |
| Grant date | Sep 11, 2012 |
| Priority date | — |
| Expiry date | May 15, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/105
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Subjects lacking Nfat1 display osteoarthritis in weight-bearing joints. Osteoarthritic changes associated with Nfat1 deficiency are characterized by articular cartilage degradation, articular chondrocyte proliferation/clustering, progressive articular surface destruction, periarticular chondro-osteophyte formation, and exposure of thickened subchondral bone. Methods of treating osteoarthritis, methods of diagnosis and early prediction of the onset of osteoarthritis, and methods for screening drug candidates that may be useful for treatment of osteoarthritis are presented.
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