Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins

US8263558B2 · kind B2 · utility

Assignees

• Abbott Laboratories · US
• Abbott GmbH & Co. KG · DE

Inventors

• Thomas F. Holzman · Libertyville, US
• John E. Harlan · Lake Zurich, US
• Rohinton P. Edalji · Wadsworth, US
• Edward T. Olejniczak · Grayslake, US
• Ana Pereda-Lopez · Mundelein, US
• Boris Labkovsky · Framingham, US
• Liping Yu · Mountain View, US
• Heinz Hillen · Herbrechtingen, DE
• Stefan Barghorn · Mannheim, DE
• Ulrich Ebert · Mannheim, DE

Key dates

• Filing date: Nov 30, 2006
• Grant date: Sep 11, 2012
• Expiry date: Dec 12, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.