Dual alanyl aminopeptidase and dipeptidyl peptidase iv inhibitors for functionally influencing different cells and for treating immunological inflammatory, neuronal and other diseases

US8263636B2 · kind B2 · utility

Assignees

• IMTM GmbH · DE
• Keyneurotek Pharmaceuticals AG · DE

Inventors

• Siegfried Ansorge · Hohenwarthe, DE
• Ute Bank · Staßfurt, DE
• Karsten Nordhoff · Magdeburg, DE
• Michael Taeger · Heinrichsberg, DE
• Frank Striggow · Gerwisch, DE

Key dates

• Filing date: Oct 15, 2004
• Grant date: Sep 11, 2012
• Expiry date: Jul 11, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substances capable of specifically inhibiting Ala-p-nitroanilide-cleaving peptidases and Gly-Pro-p-nitroanilide-cleaving peptidases as well, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).