pH-sensitive polymeric micelles for drug delivery
US8263664B2 · kind B2 · utility
3Cited by
3References
19Claims
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Key dates
| Filing date | Jun 18, 2009 |
| Grant date | Sep 11, 2012 |
| Priority date | — |
| Expiry date | Oct 18, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.