Humanized antibodies against TL1A

US8263743B2 · kind B2 · utility

Assignee

• TEV A Biopharmaceuticals USA, Inc. · US

Inventors

• Rodger Smith · Jefferson, US
• Palanisamy Kanakaraj · Germantown, US
• Viktor Roschke · Rockville, US
• Craig Rosen · Laytonsville, US
• Bridget A. Cooksey · Rockville, US

Key dates

• Filing date: Nov 13, 2008
• Grant date: Sep 11, 2012
• Expiry date: Oct 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are humanized antibodies that bind specifically to the receptor TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function.