Patent · US Active

Anti-CD38 human antibodies and uses thereof

US8263746B2 · kind B2 · utility

23Cited by

6References

28Claims

0Family size

Assignee

MORPHOSYS AG · DE

Inventors

Michael Tesar · Heidelberg, DE
Ute Jäger · Höchst im Odenwald, DE

Key dates

Filing date	Feb 7, 2005
Grant date	Sep 11, 2012
Priority date	—
Expiry date	Jan 27, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated with malignancies. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use therefore.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.