Process for the stereoselective preparation of bicyclic heterocycles

US8263768B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Markus Ostermeier · Biberach an der Riß, DE
• Stefan Braith · Warthausen, DE
• Juergen Daeubler · Biberach an der Riß, DE
• Guenther Huchler · Biberach an der Riß, DE
• Waldemar Pfrengle · Seibersbach, DE

Key dates

• Filing date: Jul 23, 2009
• Grant date: Sep 11, 2012
• Expiry date: Jul 23, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the stereoselective preparation of compounds of general formula (I)and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways.