Process for the sulfinylation of a pyrazole derivative

US8263783B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Martin Sukopp · Mannheim, DE
• Oliver Kuhn · Konz, DE
• Carsten Groning · Mannheim, DE
• Michael Keil · Freinsheim, DE
• Jon J. Longlet · Nederland, US

Key dates

• Filing date: Nov 5, 2007
• Grant date: Sep 11, 2012
• Expiry date: Jun 2, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P33/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.