Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof

US8268326B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Yvonne Paterson · Philadelphia, US
• Paulo Maciag · Long Grove, US
• Matthew Seavey · Secane, US
• Soldano Ferrone · Buffalo, US

Key dates

• Filing date: Oct 3, 2008
• Grant date: Sep 18, 2012
• Expiry date: Dec 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/95
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant Listeria strains comprising same, and methods of inducing an anti-HMW-MAA and anti HER-2/neu immune response thus treating and impeding the growth of tumors, comprising administering same.