Patent · US Active

Polymide nucleic acid derivatives, and agents and processes for preparing them

US8268560B2 · kind B2 · utility

1Cited by

5References

9Claims

0Family size

Assignee

Sanofi-Aventis Deutschland GMBH · DE

Inventors

Eugen Uhlmann · Königstein, DE
Gerhard Breipohl · Scheinfeld, DE
David William Will · Schwalbach, DE

Key dates

Filing date	Jan 24, 2011
Grant date	Sep 18, 2012
Priority date	—
Expiry date	Jan 24, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T436/143333
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.