Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the disease
US8268577B2 · kind B2 · utility
2Cited by
1References
27Claims
0Family size
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Key dates
| Filing date | Mar 5, 2009 |
| Grant date | Sep 18, 2012 |
| Priority date | — |
| Expiry date | Aug 13, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/42
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.