Expression, purification and uses of a plasmodium falciparum liver stage antigen 1 polypeptide

US8268615B2 · kind B2 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• David Lanar · Takoma Park, US
• Collette J. Hillier · Chatswood, AU
• Jeffrey A. Lyon · Woodinville, US
• Evelina Angov · Bethesda, US
• Sanjai Kumar · Gaithersburg, US
• William Rogers · Rockville, US
• Arnoldo Barbosa · Ortega, CO

Key dates

• Filing date: May 14, 2009
• Grant date: Sep 18, 2012
• Expiry date: Jun 16, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A90/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) LSA-NRC polypeptide. The method of the present invention produces a highly purified polypeptide which is useful as a vaccine and as a diagnostic reagent.