Composition and method for preparing plasminogen
US8268782B2 · kind B2 · utility
5Cited by
47References
15Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 6, 2009 |
| Grant date | Sep 18, 2012 |
| Priority date | — |
| Expiry date | Mar 6, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is both a method for preparing a plasminogen and a method for preparing a reversibly inactive acidified plasmin by activating the plasminogen. The prepared plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluted at a low pH. The prepared plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.