Pyridazinone derivatives as PARP inhibitors

US8268827B2 · kind B2 · utility

Assignee

• Istituto di Recerche di Biologia Molecolare P. Angeletti S.R.L. · IT

Inventors

• Danila Branca · Pomezia, IT
• Gabriella Dessole · Roma, IT
• Federica Ferrigno · Pomezia, IT
• Philip Jones · Houston, US
• Olaf Kinzel · Heidelberg, DE
• Samuele Lillini · Chiaravalle, IT
• Ester Muraglia · Roma, IT
• Giovanna Pescatore · Cosenza, IT
• Carsten Schultz-Fademrecht · Pomezia, IT

Key dates

• Filing date: Nov 14, 2008
• Grant date: Sep 18, 2012
• Expiry date: Mar 11, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.