Pyrimidinyl pyridone inhibitors of kinases
US8268840B2 · kind B2 · utility
5Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 29, 2009 |
| Grant date | Sep 18, 2012 |
| Priority date | — |
| Expiry date | Aug 21, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application discloses novel pyrimidinyl pyridone derivatives according to formula I, wherein A, R1, R2, R3, and mare defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.