Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof

US8268865B2 · kind B2 · utility

Assignee

• REMPEX PHARMACEUTICALS, INC. · US

Inventors

• Tomasz Glinka · Sunnyvale, US
• Olga Lomovskaya · Mill Valley, US
• Keith A. Bostian · Menlo Park, US
• David Mark Wallace · San Diego, US

Key dates

• Filing date: May 6, 2008
• Grant date: Sep 18, 2012
• Expiry date: Jun 21, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06086
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.