Contrast agents

US8273325B2 · kind B2 · utility

Assignee

• GE HEALTHCARE AS · NO

Inventors

• Helge Tolleshaug · Oslo, NO
• Alan Cuthbertson · San Jose, US
• Hege Karlsen · Oslo, NO

Key dates

• Filing date: Dec 19, 2007
• Grant date: Sep 25, 2012
• Expiry date: Jan 10, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0056
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.