Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs

US8273371B2 · kind B2 · utility

Inventors

• Johan Martens · Overijse, BE
• Christine Kirschhock · Oud-Heverlee, BE
• Sebastien Philippe Brigitte Kremer · Schaerbeek - Schaarbeek, BE
• Alexander Jan Maria Herman Eugeen Aerts · Ekeren, BE
• Guy Van Den Mooter · Pellenberg, BE
• Jan Van Humbeeck · Oud-Heverlee, BE

Key dates

• Filing date: Jul 6, 2009
• Grant date: Sep 25, 2012
• Expiry date: Nov 28, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C01B37/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.