Patent · US Active

Engineered ketoreductases and methods for producing stereoisomerically pure statins

US8273547B2 · kind B2 · utility

3Cited by

34References

14Claims

0Family size

Assignee

Codexis, Inc. · US

Inventors

Lorraine Giver · Sunnyvale, US
Lisa Marie Newman · San Jose, US
Emily Mundorff · Garden City, US
Gjalt W. Huisman · Redwood City, US
Stephane J. Jenne · Foster City, US
Jun Zhu · Chandler, US
Behnaz Behrouzian · South San Francisco, US
John H. Grate · Los Altos, US
James Lalonde · Palo Alto, US

Key dates

Filing date	Dec 23, 2010
Grant date	Sep 25, 2012
Priority date	—
Expiry date	Dec 23, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P7/62
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.