Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions

US8273787B2 · kind B2 · utility

Assignee

• ONCONOVA THERAPEUTICS, INC. · US

Inventors

• Stanley C. Bell · Narberth, US
• Glenn Fegley · Eagleville, US
• Stephen Cosenza · Voorhees, US
• Jodie Duke · Newark, US
• Reddy E Premkumar · Villanova, US
• Reddy M. V. Ramana · Blue Bell, US

Key dates

• Filing date: Sep 14, 2007
• Grant date: Sep 25, 2012
• Expiry date: Feb 20, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.