Patent · US Active

Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine

US8273857B2 · kind B2 · utility

2Cited by

51References

15Claims

0Family size

Inventors

Jen-Chang Hsia · Irvine, US
Li Ma · Statesboro, US

Key dates

Filing date	Sep 22, 2010
Grant date	Sep 25, 2012
Priority date	—
Expiry date	Oct 30, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/805
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention describes neuroprotective and multifunctional intra- and inter-molecular redox coupled polynitroxylated pegylated carboxy hemoglobins as high therapeutic index agents for un-met medical needs or diseases, which require acute or chronic alleviation of oxidative stress and correction of inadequate blood flow resulting from physical injury, ischemia, reperfusion injury, and inflammation injury in either or both pre-hospital and in-hospital transfusion and critical care medicine. These hemoglobins are triple-modified with a focus on therapeutic activities rather than oxygen carrying ability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.