Antagonists of IL-6 to prevent or treat thrombosis
US8277804B2 · kind B2 · utility
51Cited by
1References
46Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 24, 2009 |
| Grant date | Oct 2, 2012 |
| Priority date | — |
| Expiry date | Nov 27, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.