Mucosal vascular addressins and uses thereof
US8277808B2 · kind B2 · utility
0Cited by
23References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 3, 2007 |
| Grant date | Oct 2, 2012 |
| Priority date | — |
| Expiry date | Apr 3, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/866
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to isolated antibodies and antigen-binding fragments thereof that bind naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM comprises a polypeptide with at least 90% sequence identity to SEQ ID NO:2 or SEQ ID NO:4, said naturally occurring human MAdCAM binds α4β7, and wherein said isolated antibodies and antigen-binding fragments thereof inhibit binding of said naturally occurring human MAdCAM to human α4β7, and wherein said antibody inhibits adhesion of RPMI 8866 cells to cells that express said human MAdCAM.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.