Patent · US Active

RNA containing modified nucleosides and methods of use thereof

US8278036B2 · kind B2 · utility

310Cited by

0References

21Claims

0Family size

Assignee

The Trustees of the University of Pennsylvania · US

Inventors

Katalin Kariko · Rydal, US
Drew Weissman · Wynnebrook Manor, US

Key dates

Filing date	Aug 21, 2006
Grant date	Oct 2, 2012
Priority date	—
Expiry date	May 24, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2800/95
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.