Induction, propagation and isolation of liver progenitor cells
US8278105B2 · kind B2 · utility
7Cited by
0References
21Claims
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Assignee
Inventors
Key dates
| Filing date | Sep 9, 2009 |
| Grant date | Oct 2, 2012 |
| Priority date | — |
| Expiry date | Sep 9, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of induction and isolation of progenitor cells from stem cell cultures, specifically liver progenitor cells from human embryonic stem cell cultures. In one embodiment, the present invention provides a method of inducing hepatocyte-like progenitor cells by placing a quantity of human embryonic stem cells in a medium supplemented with an inhibitor of the MAPK/MEK/ERK signaling pathway, FGFR, GSK3 and/or BMP.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.