Substituted spiroamine compounds

US8278319B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Melanie Reich · Aachen, DE
• Stefan Oberboersch · Aachen, DE
• Stefan Schunk · Aachen, DE
• Ruth Jostock · Stolberg, DE
• Sabine Hees · Aachen, DE
• Michael Engels · Turnhout, BE

Key dates

• Filing date: Oct 29, 2009
• Grant date: Oct 2, 2012
• Expiry date: Aug 31, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted spiroamine compounds corresponding to the formula (I)In which m, n, o, p, Q, r, s, t, R1, R2, R3, R4a, R4b, R5a, R5b, R6a, R6b, R7, R8, R9, R10 and R11 have defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.