Patent · US Active

Dimeric high affinity EGFR constructs and uses thereof

US8278415B2 · kind B2 · utility

1Cited by

9References

2Claims

0Family size

Assignee

Centocor, Inc. · US

Inventors

Wang Bryan · Wyomissing, US
Frank Shi · Irvine, US
Juliane Mills · Wallingford, US

Key dates

Filing date	Dec 20, 2007
Grant date	Oct 2, 2012
Priority date	—
Expiry date	Dec 22, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Polypeptides comprising EGFR extracellular domains I-III capable of forming dimeric EGF-binding proteins are provided. The dimeric construct of the invention is useful in applications where high affinity EGF binding is desired and can be used to select agents capable of binding to native EGFR in the presence of EGF.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.